Anti-Catabolic Role of Mechanical Load

Principle Investigator

Peter Torzilli, PhD

Scope

For decades, the application of continuous passive motion after knee surgery has been a common practice in clinics to enhance cartilage healing and reduce joint inflammation, whereas immobilization (casting) is known to prevent cartilage repair. Similarly, it is also reported that moderate daily exercise can relieve symptoms in arthritic patients and slow down the progression of osteoarthritis, a disease currently affecting more than 20 million Americans.  The underlying mechanism for such a benefit is not completely clear. In this summer project, we are aiming to study the molecular mechanism by which physiological load counteracts pro-inflammatory signaling pathways using state-or-the-art techniques in molecule biology and mechanobiology.  The student is also expected to learn the pathogenesis of osteoarthritis and to observe surgical practice for cartilage repair.

Contact

Chris Chen, PhD
chench@hss.edu