Lupus (SLE)

Systemic Lupus Erythematosus (SLE, also known as lupus) is an autoimmune illness in which parts of the immune system, which normally protect the body from outside invaders, run amok and attack parts of the body instead.

Although there are several different forms of lupus, the classical lupus patient is usually a young woman with a combination of symptoms such as fever, swollen lymph glands, rashes (particularly butterfly-shaped rashes on the face), arthritis, fatigue, hair loss, chest and/or abdominal pain, oral ulcers, and neuropsychiatric problems such as headache, memory loss, mood disorders, and/or confusion.
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Overview Text Audio Video
Pregnancy in Autoimmune and Musculoskeletal Disease View Article View Video Presentation
Questions to Ask Your Doctor About Your Condition View Article
Inflammatory Arthritis of the Hip View Article
Hospital for Special Surgery Doctors Available to Comment on Withdrawal of Vioxx® View Article
An In-Depth Overview of Systemic Lupus Erythematosus View Article
Systemic Lupus Erythematosus - Frequently Asked Questions View Article

Diagnosis Text Audio Video
Autoimmune Disease: Does Sex Matter? View Article
Laboratory Tests in Lupus View Article

Complications & Secondary Illness Text Audio Video
Pregnancy in Autoimmune and Musculoskeletal Disease View Article View Video Presentation
Common Pulmonary Problems in Rheumatology View Article View Video Presentation
FDA Alert Regarding Lupus Medication: an HSS Rheumatology Perspective View Article
Sjogren's Syndrome and Lupus: What You Should Know View Article
Lupus and Lupus Nephritis (Kidney Inflammation) View Article
"Antiphospholipid Syndrome: Essential Information and Support" FAQs View Article
Progressive Multifocal Leukoencephalopathy (PML) in Two Lupus Patients Treated with Rituximab (Rituxan): An HSS Rheumatology Perspective View Article

Treatments Text Audio Video
Understanding Informed Consent View Article
Relaxation Imagery and Lupus: How it Can Help View Article
Interactions Between Commonly Used Medications For Lupus and Herbal Supplements View Article
Hospital for Special Surgery Doctors Available to Comment on Withdrawal of Vioxx® View Article
Guidelines for Safe Use of IVIG (Intravenous Immunoglobulin) View Article
How to Reduce Corticosteroid Side Effects View Article
Infusion Therapy Unit View Article
Your Own Best Advocate: How to be an Active Participant in Your Care View Article
Heart and Lung Involvement and Lupus: What You Need to Know View Article
Surgical Arthritis Service View Article
Targets for New SLE Treatments View Article
Acupuncture for SLE: Can it Work for You? View Article

Research Text Audio Video
An Overview of Lupus Research: Where We’ve Been and Where We’re Going View Article
Targets for New SLE Treatments View Article
Lupus Research: How it Works, What You Should Know to Participate View Article
Disease Registries in the Assessment of Autoimmune Disorders and SLE Cognitive Abnormalities View Article View Video Presentation
What's New and Important in Lupus Research View Article
The Research Proves It: For Better Health, Get Involved! View Article

Mind-Body Issues Text Audio Video
Embracing Gratitude While Coping With Lupus View Article
Interactions Between Commonly Used Medications For Lupus and Herbal Supplements View Article
Understanding Fatigue in Lupus - and What Can Be Done View Article
Can better social support improve your health in SLE? View Article

HSS Support Services Text Audio Video
LANtern® (Lupus Asian Network) View Article
Manage Your Care: VOICES Program at HSS View Article
SLE Workshop View Article
Teen and Parent Lupus Chat Groups View Article
Charla de Lupus (Lupus Chat)® View Article
LupusLine® View Article
Teens with Lupus - and Parents - Get Special Help in Chat Groups View Article
The Secret Handshake of Lupus: A Patient Roundtable View Article View Video Presentation
Finding the Right Connection for People with Lupus View Article
You're Never Alone: Volunteers Talk About Lupus Support View Article View Video Presentation

Related Conditions Text Audio Video
Antiphospholipid Antibody Syndrome - In-Depth Overview View Article
Undifferentiated Connective Tissue Disease - In-Depth Overview View Article
Undifferentiated Connective Tissue Disease (UCTD): Frequently Asked Questions View Article
The Effects of Lupus and Lupus Medications on Mood View Article
Mastering the Impact of Fatigue in Rheumatoid Arthritis View Article
Osteonecrosis (Avascular Necrosis) of the Hip View Article
Doctor-Patient Communication: An SLE Workshop Support Group summary View Article
Social Security Disability and Lupus: What You Should Know View Article
Lupus and the Skin: Manifestations, Causes, Treatments, and Research Horizons View Article
Lupus and Osteoporosis: What You Need to Know View Article
“Unlocking the Mystery of Lupus: Lupus & the Heart” FAQs View Article
Neuropsychiatric Problems in Lupus View Article
Lupus Vasculitis and Blocked Blood Vessels View Article
Lupus and Osteoporosis: A Rheumatologist’s Perspective View Article
Lupus and Fibromyalgia View Article
Lupus and Depression View Article
Systemic Lupus Erythematosus (Lupus) and Pregnancy View Article
Coping with the Emotional Impact of Rheumatic Disease View Article
Can better social support improve your health in SLE? View Article
Vaccinations and Rheumatic Disease View Article
Update on Smallpox and Flu Vaccinations View Article
Sun, Your Arthritis, and Your Medications View Article
Is there anything that can be done for hair loss as a result of taking methotrexate or other medications for lupus? View Article
How to Reduce Corticosteroid Side Effects View Article
How Lupus Can Affect the Nervous System View Article

Tips & Calculators Text Audio Video
How to Get Back to - and Stick with - Exercise View Article

HSS Support Program Summaries Text Audio Video
Lupus and Employment Rights: Knowing Your Options View Article
Finding Lupus Information on the Internet View Article
Embracing Gratitude While Coping With Lupus View Article
Lupus-related Fatigue and Cognitive Dysfunction: The Chicken and the Egg View Article
LANtern (Lupus Asian Network) View Article
Lupus Research: How it Works, What You Should Know to Participate View Article
How Lupus Can Affect the Nervous System View Article
Lupus and Lupus Nephritis (Kidney Inflammation) View Article
Thinking, Memory and Lupus: What We Know and What We Can Do View Article
The Effects of Lupus and Lupus Medications on Mood View Article
The Secret Handshake of Lupus: A Patient Roundtable View Article View Video Presentation
Doctor-Patient Communication: An SLE Workshop Support Group summary View Article
Lupus Research, Medication, and Treatment: Past, Present, and Future View Article
Lupus and Infusion Therapy: What You Should Know Now View Article
Lupus Across Cultures View Article
Oral Concerns in People With Lupus View Article
Social Security Disability and Lupus: What You Should Know View Article
Sjogren's Syndrome and Lupus: What You Should Know View Article
Lupus and the Skin: Manifestations, Causes, Treatments, and Research Horizons View Article
Lupus and Osteoporosis: What You Need to Know View Article
Interactions Between Commonly Used Medications For Lupus and Herbal Supplements View Article
Heart and Lung Involvement and Lupus: What You Need to Know View Article
Complementary and Alternative Therapies for Pain View Article
Antiphospholipid Antibody Syndrome - In-Depth Overview View Article
“Unlocking the Mystery of Lupus: Lupus & the Heart” FAQs View Article
What's New and Important in Lupus Research View Article
The SLE Workshop 20th Anniversary Celebration View Article
Taijiquan (Tai Chi Chuan) and Qigong (Chi Kung) for Health and Well-Being View Article
Physical Fitness, Physical Therapy and Lupus View Article
Managing Lupus Stress More Effectively by Changing Your Thoughts and Actions View Article
Lupus Vasculitis and Blocked Blood Vessels View Article
Lupus and Osteoporosis: A Rheumatologist’s Perspective View Article
Lupus and Fibromyalgia View Article
Lupus and Depression View Article
Systemic Lupus Erythematosus (Lupus) and Pregnancy View Article
Acupuncture for SLE: Can it Work for You? View Article
You're Never Alone: Volunteers Talk About Lupus Support View Article View Video Presentation

Clinical Trials Text Audio Video
A Phase 1b Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation study with an open-label extension to evaluate the safety and tolerability of multiple IV doses of Medi-545, a fully Human Anti-interferon-alpha Monoclonal Antibody, View Article
A Phase I, Randomized, Double-blind, Placebo-controlled, Escalating Single- and Multiple-dose Study of the Safety, Tolerability, and Pharmakokinetics of RhuMab IFN alpha in Adults with Systemic Lupus Erythematosus View Article
The Systemic Lupus Erythematosus (SLE) Activity Gene Expression (SAGE) Study View Article
A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled 76 Week Study to Evaluate the Efficacy and Safety of Belimumab (GHS1006, LymphoStat-B), A fully Human monoclonal Anti-BlyS Antibody, in Subjects with Systemic Lupus Erythematosus (SLE). View Article
A Sequential Adaptive Phase II/III Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Abatacept Versus Placebo on a Background of Mycophenolate Mofetil and Glucocorticosteroids View Article
EXPLORER: A randomized, double-blind, placebo controlled, multicenter, phase II/III study to evaluate the efficacy and safety of rituximab in subjects with moderate to severe systemic lupus erythematosus View Article
Autoimmune Disease Registry and Repository View Article
PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE) View Article
MINDFULL: A Randomized, Controlled Pilot Study of a Cognitive Rehabilitation Intervention Program in Systemic Lupus Erythematosus Patients View Article
Pilot and Feasibility Study of Modafinil Treatment to Improve Cognitive Efficiency in SLE Patients View Article
LUNAR: A phase III, randomized, double-blind, placebo-controlled, multi-center study to evaluate the efficacy and safety of rituximab in subjects with class III or IV lupus nephritis View Article
Fc Receptor Function in Normals and Systemic Lupus Erythematosus (SLE) View Article
A Phase I, Randomized, Double-Blind, Placebo Controlled, Dose-Escalation Study To Evaluate Safety And Tolerability Of A Single IV Dose Of MEDI-545, A Fully Human Monoclonal Antibody Directed Against Interferon Alpha Subtypes View Article