Dale J. Lange, MD

Dr. Dale Lange is the Chairman of Neurology and the Neurologist-in-Chief at Hospital for Special Surgery. He specializes in diseases of nerve and muscle. He received his medical degree from New York Medical College and completed his internship in medicine at Albany Medical Center. Dr. Lange completed his residency in neurology at the Tufts New England Medical Center in Boston, MA, and then became the Clinical Fellow of the Muscular Dystrophy Association in EMG and Neuromuscular Disease at the Neurological Institute at the Columbia Presbyterian Medical Center in New York.

Dr. Lange has served on the faculties of the College of Physicians and Surgeons of Columbia University and the Mount Sinai School of Medicine. He is on the faculty of Weill Cornell Medical College and is Director of the Muscular Dystrophy Association sponsored MDA/ALS and neuromuscular disease Clinics at New York Presbyterian Hospital/Weill Cornell Medical Center.

Dr. Lange’s clinical practice is focused primarily on the diagnosis and management of diseases of nerve and muscle, including motor neuron disease (ALS), peripheral neuropathy (GBS, CIDP, diabetic, toxic, metabolic neuropathies), neuromuscular junction disorders (myasthenia gravis, Lambert-Eaton myasthenic syndrome, and botulism), and myopathies (polymyositis, inclusion-body myositis and muscular dystrophies). He also performs nerve conduction, needle EMG, and single-fiber EMG studies to evaluate patients with focal and generalized neuromuscular disorders. His research interests include designing, implementing, and managing clinical trials for patients with ALS and other neuromuscular diseases.

Dr. Lange is the author of more than 90 peer reviewed articles and chapters in textbooks. He has been invited to lecture, both nationally and internationally, on topics related to his research in neuromuscular disease. Dr. Lange sees patients with complaints referable to nerve and muscle disease as well as select general neurological conditions in his office at Hospital for Special Surgery.

Appointments

Neurologist-in-Chief, Hospital for Special Surgery

Specialty

Neurology

Special Expertise

Motor Neuron Disease (ALS)
Peripheral Neuropathy
Nerve Injuries
Nerve Root Disease
Myasthenia Gravis
Muscle Disease (including Muscular Dystrophy and Polymyostis)

Awards

Henry Viets Research Fellow in Myasthenia Gravis
Charlton Research Award, Tufts University
Best Doctors in America, 2002-2008
Top Doctors: New York Metro Area, 2006-2008

Affiliations

Fellow, American Academy of Neurology
Member, American Neurological Association
Member, American Association of Neuromuscular and Electrodiagnostic Medicine

Procedures

EMG
Nerve Conduction Studies/Somatosensory Evoked Potentials/Skin Biopsies

Education

New York Medical College, Valhalla, NY, 1978

Internship

Albany Medical Center, Albany, NY, 1978-1979

Residency

Tufts New England Medical Center, Boston, MA, 1979-1982

Fellowship

Neurological Institute, Columbia College of Physicians and Surgeons, New York, 1982-1983

Certification

American Board of Psychiatry and Neurology, 1985
American Board of Psychiatry and Neurology with added qualifications in Neuromuscular Medicine, 2008
American Board of Electrodiagnostic Medicine

State Licensure

New York  

Selected Publications

Dabby R, Lange DJ, Trojaborg W, Hays AP, Lovelace RE, Brannagan TH, Rowland LP. Inclusion Body Myositis Mimicking Motor Neuron Disease. Arch Neurol 2001; 58:1253-1256.

Vahdat L, Papadopoulos K, Lange DJ, Leuin S, Rosenman P, Kaufman E, Donovan D, Frederick D, Bagiella E, Tierstin A, Nichols G, Garrett T, Savage D, Antman K, Hesdorffer CS, Balmaceda C. Reduction of Paclitaxel-induced Peripheral Neuropathy with Glutamine. Clin Cancer Res 2001;7:1192-1197.

Zhao Z, Lange DJ, Voustiaiouk A, MacGrogan D, Ho L, Suh J, Humala N, Thiyagarajan M, Wang J, Pasinetti GM. A Ketogenic Diet as a Potential Novel Therapeutic Intervention in Amyotrophic Lateral Sclerosis. BMC Neuroscience 2006;7:29-58.

Pasinetti GM, Ungar LH, Lange DJ, Yemul S, Deneg H, Yuan X, Brown RH, Cudkowicz ME, Newhall K, Peskind E, Marcus, S, Ho, L. Identification of Potential CSF Biomarkers in Amyotrophic Lateral Sclerosis. Neurology 2006; 66:1218-1222.

Lange DJ, DeAngelis T, Sivak M. Single Fiber EMG Shows Terminal Axon Dysfunction in Miller Fisher Syndrome. Muscle Nerve 2006; 34:232-234.

Lange DJ, Lechtzin N, Davey C, Gelinas D, Heiman-Patterton T, David W, Becker B, Mitsumoto H. A Randomized, Controlled Trial of High Frequency Chest Wall Oscillation in ALS. Neurology 2006; 26: 991-997.

Lange DJ, Weimer L, Gooch CL, Lovelace RE, Trojaborg W, Rowland LP. Multifocal Motor Neuropathy with Conduction Block: Slow But Not Benign. Archives of Neurology. 2006; 63:1778-1181.

Lechtzin N, Lange DJ, Davey C, David W, Heiman-Patterson T, Gelinas D, Becker B, Kimball R, Mitsumoto H. Measures of Dyspnea in Patients with Amyotrophic Lateral Sclerosis. Muscle Nerve 2007; 35: 98-102.

Voustianiouk A, Seidel G, Panchal J, Czaplinski A, Yen A, Appel SH, Lange DJ. ALSFRS and Appel ALS Scores: Discordance with Disease Progression. Muscle Nerve 2008; 37:668-672.

Zhao Z, Lange DJ, Ho L, Bonini S, Shao B, Salton SR, Thomas S, Pasinetti GM. VGF is a Novel Biomarker Associated with Weakness in Amyotrophic Lateral Sclerosis (ALS), With a Potential Role in Disease Pathogenesis. Int J Med Sci 2008; 5: 92-99.

For more publications, please see the PubMed listing.

Selected Books/Chapters

Lange DJ, Trojaborg W. Electromyography and Nerve Conduction Studies. Rowland LP, ed, Tenth edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2000: 73-77.

Lange DJ, Latov N, Trojaborg W. Acquired Neuropathies. In Merritt’s Textbook of Neurology. Rowland LP, ed, Tenth edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2000: 613-633.

Lange DJ, Trojaborg W, Rowland LP. Peripheral and Cranial Nerve Lesions. In: Merritts Textbook of Neurology. Rowland LP, ed, Tenth edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2000: 436-434.

Kissel JT, Amato AA, Barohn RJ, Iannaccone ST, Lange DJ, Mendell JR. Muscle Disease. Continuum - Lifelong Learning in Neurology, 2000; 6:1-227.

Lange DJ, Tolunsky, E. Infections of Peripheral Nerve. Neuromuscular Function and Disease. Electrodiagnostic Medicine. Brown WF, Bolton C, Aminoff M, eds.  Lippincott Williams & Wilkins Philadelphia, PA. 2002; 1251-1253.

Gooch C, Lange DJ, Trojaborg W. Peripheral and Cranial Nerve Lesions. In: Rowland LP, ed, Eleventh edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2005: 523-543.

Robinson-Papp J, Lange DJ. Immune Mediated Demyelinating Neuropathies. Up To Date. 2008 (in press).

Selected Presentations

Invited Lecture Packard Center Annual Meeting, Johns Hopkins Medical Center, Baltimore, MD, April, 2009
Invited Lecture: ALS/MND Meeting Birmingham, England, December, 2008
Invited Lecture: ALS TDI Leadership Summit, Boston, MA, September, 2008  

Research Interests

Clinical Trials in Neuromuscular Disease (including ALS)
Transcranial Magnetic Stimulation