Madhu M. Bhargava, PhD

Appointments

Associate Scientist, Hospital for Special Surgery

 

Selected Publications

Hannafin JA, Attia EA, Henshaw R, Bhargava MM. Effect of Cyclic Strain and Plating Matrix on Cell Proliferation and Integrin Expression by Ligament Fibroblasts. J. Orthop Res. In press.

Bhargava MM, Attia E, Dolan M, Murrell GAG, Warren RF, and Hannafin JA. Effect of cytokines on proliferation and migration of bovine meniscal cells. Amer. J. Sports Med. 27:636-643, 1999.

Tsuzaki M, Brigman BE, Yamamoto J, Lawrence TW, Simmons JG, Mohopatra NK, Lund PK, Van Wyk J, Hannafin JA, Bhargava MM, Banes AJ. IGF-1 is expressed by avian tendon cells. J. Orthop. Res., 18:546-556,2000.

Suzuki K, Attia ET, Hannafin JA, Rodeo SA, Warren RF, Bhargava MM. The effect of cytokines on the migration of fibroblasts derived from different regions of the canine shoulder capsule. The Journal of Shoulder and Elbow Surgery. 10:62-67, 2001.

Chen CT, Bhargava MM, Lin P, Torzilli PA. Time and zone dependent chondrocyte death in cyclically loaded articular cartilage. J. Orthop. Res. 21:888-898, 2003.

For more publications, please see the PubMed listing.  

Research Description

Tissue Engineering of Ligaments/Chondroprotection/Molecular interactions between mechanical load and inflammatory cytokines in degradation of cartilage matrix in OA/RA.

In collaboration with Jo Hannafin, MD, PhD, we are determining the effects of mechanical strain and cytokines on cell proliferation and matrix turnover in ligaments to determine the optimal conditions for tissue engineering a ligament. In collaboration with Peter Torzilli, PhD, and Chisa Hidaka, MD, we are exploring the molecular mechanisms involved in cartilage matrix degradation by mechanical load and inflammatory cytokines in OA/RA . In collaboration with Peter Torzilli, PhD, we are exploring ways to modify the cartilage surface so that it becomes more resistant to breakdown by MMPs and mechanical shear.